Put simply, Compassion Fatigue is a diminished ability to be compassionate, often the result of exhaustion in caregiving.  It is distinct from Burnout which involves emotional exhaustion.  However, burnout is usually caused by increased workload and stress.  Compassion Fatigue differs in that it is directly related to caregiving, often as it involves trauma.  

People who are susceptible to Compassion Fatigue include, nurses, counselors, pastors, aid workers, parents of special needs children, family members of disabled persons, and anyone who gives care to people in need or crisis.